infliximab, a monoclonal antibody. ▪ INDICATIONS: It is used to treat moderate to severe fistulizing Crohn’s disease. ▪ CONTRAINDICATIONS: Known hypersensitivity to murines prohibits its use. ▪ ADVERSE EFFECTS: Life-threatening effects include anaphylaxis, anemia, and tachycardia. Other adverse effects include dry skin, sweating, flushing, hematoma, pruritus, upper respiratory infection, pharyngitis, bronchitis, cough, dyspnea, sinusitis, myalgia, back pain, arthralgia, dysuria, urinary frequency, chest pain, hypertension, and hypotension. Common side effects include nausea, vomiting, abdominal pain, stomatitis, constipation, dyspepsia, flatulence, headache, dizziness, depression, vertigo, fatigue, anxiety, fever, rash, dermatitis, and urticaria.
