ifosfamide, an antineoplastic alkylating agent. ▪ INDICATIONS: This drug is used to treat testicular cancer, soft tissue sarcoma, Ewing’s sarcoma, non-Hodgkin’s lymphoma, lung sarcoma, and pancreatic sarcoma. ▪ CONTRAINDICATIONS: Pregnancy, bone marrow suppression, and known hypersensitivity to this drug prohibit its use. ▪ ADVERSE EFFECTS: Adverse effects of this drug include facial paresthesia, fever, malaise, somnolence, confusion, depression, hallucinations, dizziness, disorientation, cranial nerve dysfunction, nausea, vomiting, anorexia, stomatitis, constipation, diarrhea, dysuria, urinary frequency, dermatitis, alopecia, and pain at the injection site. Life-threatening side effects include seizures, coma, hepatoxicity, hematuria, nephrotoxicity, hemorrhagic cystitis, thrombocytopenia, leukopenia, and anemia.
