amniotic band disruption sequence syndrome, an abnormal condition of fetal development characterized by the development of fibrous bands within the uterus that entangle the fetus, leading to deformities in structure and function. The syndrome is associated with a variety of congenital anomalies, including clubfoot, missing limbs, simian creases, and skull and visceral defects. It can be detected in the uterus. Interventions are specific to the varied symptoms, and genetic counseling is suggested. Also called amniotic band syndrome (ABS).