hypobetalipoproteinemia /hī′pōbā′təlip′ōprō′tēnē″mē·ə/ [Gk, hypo + beta, second letter of Greek alphabet, lipos, fat, proteios, first rank, haima, blood] , an inherited disorder in which there are less than normal amounts of beta-lipoprotein in the serum. Blood lipids and cholesterol are present at less than the expected levels regardless of dietary intake of fats. There are no clinical signs, and treatment is unnecessary. Compare hyperbetalipoproteinemia.