hypertrophic gastritis, a premalignant condition characterized by inflammation of the gastric mucosa associated with gastric albumin wasting. Symptoms include epigastric pain, nausea, vomiting, weight loss, and abdominal distension. It is differentiated from other forms of gastritis by the presence of prominent rugae (folds), enlarged glands, excess mucus production, and nodules on the wall of the stomach. This condition often accompanies peptic ulcer, Zollinger-Ellison syndrome, or gastric hypersecretion.