Hu antigen, a family of four RNA-binding proteins (HuD, HuC/ple21, Hel-N1, and Hel-N2) that are expressed in neurons and are believed to play an important role in the development and maintenance of the nervous system. They are also expressed in the cells of small cell lung carcinoma, sarcoma, and neuroblastoma, and antibodies to them are associated with neurological paraneoplastic syndromes.
