amifostine, a cytoprotective agent for cisplatin. ▪ INDICATIONS: This drug is used to reduce renal toxicity when cisplatin is given to treat ovarian carcinoma. It also reduces xerostomia in radiotherapy for head and neck cancer. ▪ CONTRAINDICATIONS: Known hypersensitivity to mannitol or aminothiol, hypotension, dehydration, and lactation prohibit the use of this drug. ▪ ADVERSE EFFECTS: Dizziness, somnolence, sneezing, flushing, hiccups, hypocalcemia, rash, and chills are among this drug’s side effects. Common side effects include hypotension, nausea, and vomiting.
