amide local anesthetic

amide local anesthetic, any of the numerous compounds containing an amide chemical group that blocks nerve transmission. Amides are metabolized by microsomal P-450 enzymes in the liver. Kinds include bupivacaine hydrochloride, lidocaine hydrochloride, ropivacaine, articaine, mepivacaine, prilocaine hydrochloride. See also ester local anesthetic.