highest intercostal vein [ME, heigh + L, inter, between, costa, rib, vena, vein] , one of a pair of veins that drain the blood from the upper two or three intercostal spaces. The right vein descends and opens into the azygous vein. The left vein crosses the arch of the aorta and opens into the left brachiocephalic vein, usually receiving the left bronchial vein.