hemoglobin C (Hb C), an autosomal-recessive qualitative hemoglobinopathy in which lysine is substituted for glutamic acid at position 6 of the beta globin chain. Deoxygenated red cells crystallize to form a hexagonal “bar of gold” crystal that slows their passage. Target cells are prominent. Hemoglobin C migrates slowly in hemoglobin electrophoresis, a trait used to identify its presence.
