ameba /əmē″bə/ pl. amebae, amebas [Gk, amoibe, change] , a microscopic, single-celled, parasitic organism. Several species may be parasitic in humans, including Entamoeba histolytica and E. coli, a nonpathogenic species of Entamoeba often confused with E. histolytica. Also spelled amoeba. −amebic, adj.