generalized anxiety disorder (GAD), an anxiety reaction characterized by persistent apprehension. The symptoms range from mild, chronic tenseness, with feelings of timidity, fatigue, apprehension, and indecisiveness, to more intense states of restlessness and irritability that may lead to aggressive acts. In extreme cases the overwhelming emotional discomfort is accompanied by physical reactions, including tremor, sustained muscle tension, tachycardia, dyspnea, hypertension, increased respiration, and profuse perspiration. Other physical signs include changes in skin color, nausea, vomiting, diarrhea, restlessness, immobilization, insomnia, and changes in appetite, all occurring without underlying organic cause. The symptoms of anxiety may be controlled with medication, such as tranquilizers, but psychotherapy is the preferred treatment. Also called anxiety reaction, anxiety state. See also anxiety, anxiety attack.