guanabenz acetate /gwan′abenz/ , a centrally acting alpha2 adrenergic agonist that decreases sympathetic nervous system tone. ▪ INDICATIONS: It is prescribed in the treatment of hypertension. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: Among adverse effects are dizziness, sedation, and dry mouth.