alprostadil, a proprietary form of prostaglandin E1 used to treat impotence and (temporarily) to maintain the patency of the ductus arteriosus in certain neonates. ▪ INDICATIONS: It is recommended as palliative therapy for neonates awaiting surgery to correct congenital cardiac anomalies, such as tetralogy of Fallot and tricuspid atresia. ▪ CONTRAINDICATIONS: It is contraindicated in respiratory distress syndrome and in cases of known hypersensitivity. This drug is contraindicated in pregnant patients. ▪ ADVERSE EFFECTS: The most common adverse effects are apnea, fever, seizures, cerebral bleeding, flushing, bradycardia, and hypertension.
