focal glomerular sclerosis, focal sclerosing lesions of renal glomeruli with proteinuria, hematuria, hypertension, and the nephrotic syndrome. It may be idiopathic or secondary to other conditions, including heroin-abuse nephropathy, chronic interstitial nephritis, and malignancies. Exacerbations and remissions may occur, most often in children; progression to renal failure occurs at a variable and unpredictable rate. Also called focal glomerulosclerosis.
