fluoxetine hydrochloride /flo̅o̅·ok″sətēn/ , an oral antidepressant that acts by selectively preventing serotonin reuptake. ▪ INDICATIONS: It is prescribed for major depressive disorder, obsessive-compulsive disorder, and bulimia nervosa. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: Serious adverse effects include seizures, hemorrhage, tachycardia, bradycardia, myocardial infarction, and thrombophlebitis.