flucytosine /flo̅o̅sī″təsēn/ , an antifungal drug. ▪ INDICATIONS: It is prescribed as an adjunct in the treatment of certain serious fungal infections, usually Candida or Cryptococcus. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug prohibits its use. Close monitoring is required when administering it to patients with renal disorders, bone marrow depression, or AIDS. ▪ ADVERSE EFFECTS: Among the more serious adverse effects are GI disturbances, including enterocolitis, abnormal liver function, hepatomegaly, and bone marrow depression. Also causes hallucinations, confusion and other CNS effects, respiratory depression, peripheral neuropathy, and hearing loss.
