Felty’s syndrome /fel″tēz/ [Augustus R. Felty, American physician, 1895–1963] , a group of pathological changes that occurs in adults with rheumatoid arthritis, characterized by splenomegaly, leukopenia, frequent infections, and sometimes thrombocytopenia and anemia. The cause of the syndrome is unknown. Surgical resection of the spleen offers temporary improvement in about one half of the cases. See also hypersplenism.