fatigue /fətēg″/ [L, fatigare, to tire] , 1. a state of exhaustion or a loss of strength or endurance, such as may follow strenuous physical activity. 2. loss of ability of tissues to respond to stimuli that normally evoke muscular contraction or other activity. Muscle cells generally require a refractory or recovery period after activity, when cells restore their energy supplies and excrete metabolic waste products. 3. an emotional state associated with extreme or extended exposure to psychic pressure, as in battle or combat fatigue.
