epidermolytic hyperkeratosis [Gk, epi + derma, skin + lysis, loosening; Gk, hyper, excess + keras, horn + osis, condition] , a rare autosomal-dominant form of ichthyosis with a high frequency of spontaneous mutations. Present at birth, it is characterized by generalized erythroderma and severe hyperkeratosis with small wartlike scales over the entire body, especially in body folds, and sometimes on the palms and soles. There are also recurrent bullae on the lower limbs. If sepsis and electrolyte imbalances are not treated correctly in neonates, morbidity can occur. Also called bullous congenital ichthyosiform erythroderma. See also ichthyosis.
