Alagille’s syndrome /ä·lä·zhēl′/ [Daniel Alagille, French pediatrician, 1925–2005] , an autosomal-dominant syndrome that affects the liver, heart, kidney, and other systems of the body. Can be associated with neonatal jaundice, cholestasis with peripheral pulmonary stenosis, and occasionally septal defects or patent ductus arteriosus, resulting from a low number or an absence of intrahepatic bile ducts. It is characterized by unusual facies and ocular, vertebral, and nervous system abnormalities.
