Ehlers-Danlos syndrome /ā″lərz dan″ləs/ [Edward Ehlers, Danish physician, 1863–1937; Henri A. Danlos, French physician, 1844–1912] , a hereditary disorder of connective tissue, marked by hyperplasticity of skin, tissue fragility, and hypermotility of joints. Minor trauma may cause a gaping wound with little bleeding. Sprains, joint dislocations, and synovial effusions are common. However, life expectancy is usually normal. Treatment includes symptomatic therapy, emotional support for the patient and family, and emphasis on avoiding trauma in childhood.