agranulocytosis /āgran′yo͝olō′sītō″sis/ , severe reduction in the number of granulocytic leukocytes (basophils, eosinophils, and neutrophils). Reduction in polymorphonuclear neutrophils is neutrophilia, whereby the body is severely depleted in its ability to defend itself from bacterial infection. The acute disease may be an adverse reaction to a medication or the result of the effect of radiation therapy or chemotherapy on bone marrow
