DOXOrubicin hydrochloride /dok′səro̅o̅″bisin/ , an anthracycline antibiotic. ▪ INDICATIONS: It is prescribed in the treatment of a wide variety of malignant neoplastic diseases, including leukemias, lymphomas, sarcomas, germ cell tumors, and carcinomas (e.g., lung, breast, prostate, ovary). ▪ CONTRAINDICATIONS: Myelosuppression, heart disease, concurrent administration of daunorubicin, or known hypersensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: Among the more serious adverse reactions are myelosuppression and cardiomyopathy. Stomatitis, GI disturbances, and alopecia commonly occur.
