donepezil, a reversible cholinesterase. ▪ INDICATIONS: It is used to treat mild to moderate dementia in Alzheimer’s disease. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug or to piperidine derivatives prohibits its use. ▪ ADVERSE EFFECTS: Life-threatening effects include seizures and atrial fibrillation. Other adverse effects are dizziness, somnolence, fatigue, abnormal dreams, syncope, hypotension or hypertension, anorexia, urinary frequency, urinary tract infection, incontinence, rash, flushing, rhinitis, upper respiratory infection, cough, pharyngitis, cramps, and arthritis. Common side effects include insomnia, headache, nausea, vomiting, and diarrhea.
