age-associated cognitive impairment, a progressive decline in cognitive function that occurs as a result of the normal aging process. It can be caused by a number of factors, including nutrient deficiencies, the damaging effect of free radicals, adverse effects of medication, altered hormone balance, and decreased oxygen supply to brain cells. Its near-universality causes it to be confused with mild cognitive impairment or the very early stages of some dementias; careful testing and analysis are required.