dexamethasone /dek′səmeth″əsōn/ , a long-acting synthetic adrenocorticoid with intense antiinflammatory activity and mineralocorticoid activity. ▪ INDICATIONS: It is prescribed topically and systemically in the treatment of inflammatory conditions. ▪ CONTRAINDICATIONS: Systemic fungal infections or known hypersensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: Among the more serious adverse reactions are GI, endocrine, neurological, fluid, and electrolyte disturbances.