desmopressin acetate /dez′mōpres″in/ , a synthetic antidiuretic analog of arginine vasopressin, the naturally occurring human antidiuretic hormone. ▪ INDICATIONS: It is prescribed as an antidiuretic in the treatment of diabetes insipidus and primary nocturnal enuresis and is used to control bleeding in hemophilia A and mild von Wildebrand’s disease. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug, hemophilia B, and severe von Wildebrand’s disease (IIB) prohibit its use. ▪ ADVERSE EFFECTS: Among the most serious adverse reactions are hyponatremia and water intoxication, which are seen more often when the drug is used for hemostatis. Mild effects, such as headache, cramps, and nasal congestion, also may occur.
