dentinogenesis imperfecta, 1. a genetic disturbance in the consistency of the dentin, characterized by early calcification of the pulp chambers, marked attrition, and an opalescent hue of the teeth. A form of dentin dysplasia. 2. a localized form of mesodermal dysplasia affecting the dentin of the teeth. It may be hereditary and associated with osteogenesis imperfecta. 3. a genetic condition that produces defective dentin but normal tooth enamel. Also called hereditary opalescent dentin.