danazol /dan″əzol/ , a synthetic androgen that acts to suppress the output of gonadotropins from the pituitary, suppress ovarian hormone production, and directly block ovarian hormone receptors. ▪ INDICATIONS: It is prescribed in the treatment of endometriosis, fibrocystic breast disease, and hereditary angioedema when alternative hormonal therapy is ineffective, contraindicated, or intolerable. ▪ CONTRAINDICATIONS: Genital bleeding; cardiac, liver, or kidney dysfunction; or known hypersensitivity to this drug prohibits its use. It is not prescribed during pregnancy or lactation. ▪ ADVERSE EFFECTS: Among the most serious adverse reactions are muscle spasms, nausea, weight gain, acne, edema, oily skin, voice changes, and other androgenic effects.
