cycloSERINE /sī′klōser″ēn/ , an antibiotic. ▪ INDICATIONS: It is prescribed in the treatment of active pulmonary and extrapulmonary tuberculosis. ▪ CONTRAINDICATIONS: Epilepsy, depression, severe anxiety, psychosis, severe renal insufficiency, excessive concurrent use of alcohol, or known hypersensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: Among the most serious reactions are central nervous system toxic effects, including tremor, drowsiness, convulsions, and psychotic changes. Pyridoxine may be given concurrently to prevent these effects. Other side effects include arrhythmias and optic neuritis.
