cryoglobulinemia /krī′ōglob′yo͝olinē″mē·ə/ [Gk, kryos + L, globulus, small sphere; Gk, haima, blood] , the presence of cryoglobulins in the blood. Presence of cryoglobulins may be associated with a variety of clinical disorders including Waldenström’s macroglobulinemia, hepatitis C, multiple myeloma, and leukemia.